Issue 4/2009

Release date: 11/05/2009

EDITORIAL

Innovation Welcome!

Prof. Dr. C.M.H. Claussen, European ScreeningPort, Germany

page 03

EVENTS

International Conference Discovery Partnerships

page 06

Explore Drug Transporter Routes to Enhance Drug Efficacy

page 08

DRUG DISCOVERY

Fluorescence Lifetime Assays

A Smart Solution for Inhibitor Profiling on Protease Panels

Dr. U. Hassiepen et al., Novartis Pharma, Switzerland

page 011

ELRIG MEETING

Pathway-based Target Identification and Validation

Dr. F.-J. Müller et al., Zentrum für Integrative Psychatrie (ZIP), Germany

page 014

EVENTS

LabAutomation2010

page 016

HIGH CONTENT SCREENING

FRET and Translocation in Cell-based Imaging

Challenging the Limits for HCS

Dr. A. Piljić, Dr. C. Schultz, European Molecular Biology Laboratory (EMBL), Germany

page 017

INTERVIEW

Development of Next Generation Sequencing Technology

Prof. E. Cuppen, Hubrecht Institute, The Netherlands

page 020

BUSINESS

Corporate Drug Discovery

What Can We Learn from Academia?

D. Hotz, Dr. B. Baumeister, PricewaterhouseCoopers Basel, Switzerland

page 022

APPLICATION NOTES

High Content Screening (HCS)

Meeting Future Needs of Drug Discovery

N. Thomas, GE Healthcare, United Kingdom

page 024

3-Dimensional Cell Culture

A Novel Cell Substrate Enables Modernization of Culture

N.A. Badr et al., Global Cell Solutions, USA

page 026

Enabling Kinetic Studies of GPCRs

Live-Cell, Non-Lytic Biosensor for GPCR Profiling

N. Cosby, PhD, Drug Screening Promega Corporation, USA

page 028

Semi-automated Yeast Two-hybrid Screening

A. Hermant et al., INSERM, Marseille Cancer Research Center, France

page 030

Migration Assay for High Throughput Screening (HTS)

H. Hundsberger, University of Applied Science Krems, Austria

page 032

ADVERTORIAL

Assay-ready Serial Dilution Plates

Rapid Generation Using Two-stage Low Volume Pipetting

J. Jenkins, TTP LabTech, United Kingdom

page 034